The death receptor CD95 activates the cofilin pathway to stimulate tumor cell invasion
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چکیده
Both referees agree that your results are novel, important and of broad interest. However, both have serious concerns about the strength of the conclusions you are able to draw from your current experiments and ask that you undertake work to improve the evidence presented. Both agree that your final conclusion, that CD95 stimulation activates PLCgamma1 via PDGFR, is not yet well supported by the data.
منابع مشابه
The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion.
The death receptor CD95 promotes apoptosis through well-defined signalling pathways. In colorectal cancer cells, CD95 primarily stimulates migration and invasion through pathways that are incompletely understood. Here, we identify a new CD95-activated tyrosine kinase pathway that is essential for CD95-stimulated tumour cell invasion. We show that CD95 promotes Tyr 783 phosphorylation of phospho...
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BACKGROUND Two receptors that contain the so-called "death domain' have been described to date: tumor necrosis factor receptor 1 (TNFR1) and Fas/Apo-1 (CD95); both belong to the TNFR gene family. The death domain of TNFR1 mediates the activation of programmed cell death (apoptosis) and of the transcription factor NF-kappa B, whereas the death domain of CD95 only appears to activate apoptosis. ...
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تاریخ انتشار 2011